Habilitation lecture by Ondřej Sedláček
Novel approaches in poly(2-oxazoline) synthesis for drug delivery and biocompatible coatings
The habilitation lecture focuses on the synthesis and development of novel poly(2-oxazoline)s (PAOx) with potential biomedical applications, particularly in drug delivery systems, surface biocompatibility, and responsive nanomaterials. The lecture will begin with a discussion on the development of an acylation protocol for polyethylene imine (PEI), enabling the synthesis of highly defined poly(2-oxazoline)s, which overcome the limitations of traditional cationic ring-opening polymerization (CROP). The research further explores the conjugation of PAOx with therapeutic agents, demonstrating their efficacy in drug delivery applications. The introduction of novel amphiphilic gradient copolymers based on PAOx also offers new opportunities for encapsulating hydrophobic drugs and self-assembling into nanoparticles. Finally, the lecture will highlight the superior antifouling properties of poly(2-oxazine)s, presenting these polymers as highly efficient coatings for biomedical devices, surpassing traditional materials like polyethylene oxide.
