Plain text, RIS, BibTex Journal Articles by T. Obsil K. Kohoutova, D. Kosek, A. Brzezina, K. Honzejkova, V. Obsilova and T. Obsil Structural basis of the cyclin Y/14-3-3 protein-mediated activation of CDK16 Nature Communications, 2026 DOI BibTeX M. Janosev, T. Obsil and V. Obsilova Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation The FEBS Journal, 2026 DOI BibTeX K. Kohoutova, P. Srb, V. Obsilova, V. Veverka and T. Obsil Structural plasticity of the FOXO-DBD:p53-TAD interaction Nature Communications 16(1), 2025 DOI BibTeX K. Kohoutova, P. Srb, V. Obsilova, V. Veverka and T. Obsil Structural plasticity of the FOXO-DBD:p53-TAD interaction Nature Communications 16(1), 2025 DOI BibTeX M. Janosev, D. Kosek, A. Tekel, R. Joshi, K. Honzejkova, P. Pohl, T. Obsil and V. Obsilova Structural basis of ubiquitin ligase Nedd4-2 autoinhibition and regulation by calcium and 14-3-3 proteins Nature Communications 16(1), 2025 DOI BibTeX V. Obsilova and T. Obsil Look for the Scaffold: Multifaceted Regulation of Enzyme Activity by 14-3-3 Proteins Physiol Res, 2024 BibTeX K. Honzejkova, D. Kosek, V. Obsilova and T. Obsil The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1 eLife 13, 2024 DOI BibTeX V. Obsilova and T. Obsil The yeast 14-3-3 proteins Bmh1 and Bmh2 regulate key signaling pathways Frontiers in Molecular Biosciences 11, 2024 DOI BibTeX B. A. Somsen, E. Sijbesma, S. Leysen, K. Honzejkova, E. J. Visser, P. J. Cossar, T. Obsil, L. Brunsveld et al. Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex Journal of Biological Chemistry 299(7), 2023 DOI BibTeX nuclear receptorsprotein–protein interactionsestrogen receptor14-3-3 proteinppi stabilization V. Obsilova and T. Obsil Structural insights into the functional roles of 14-3-3 proteins Frontiers in Molecular Biosciences 9, 2022 DOI BibTeX K. Kohoutova, V. Docekal, M. J. Ausserlechner, N. Kaiser, A. Tekel, R. Mandal, M. Horvath, V. Obsilova et al. Lengthening the Guanidine–Aryl Linker of Phenylpyrimidinylguanidines Increases Their Potency as Inhibitors of FOXO3-Induced Gene Transcription ACS Omega 7(38), 2022 DOI BibTeX R. Mandal, K. Kohoutova, O. Petrvalska, M. Horvath, P. Srb, V. Veverka, V. Obsilova and T. Obsil FOXO4 interacts with p53 TAD and CRD and inhibits its binding to DNA Protein Science 31(5), 2022 DOI BibTeX R. Joshi, P. Pohl, D. Strachotova, P. Herman, T. Obsil and V. Obsilova Nedd4-2 binding to 14-3-3 modulates the accessibility of its catalytic site and WW domains Biophysical Journal 121(7), 2022 DOI BibTeX P. Pohl, R. Joshi, O. Petrvalska, T. Obsil and Obsilova V 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains Commun. Biol., 2021 DOI BibTeX M. Horvath, O. Petrvalska, P. Herman, V. Obsilova and T. Obsil 14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites Communications Biology 4(986), 2021 DOI BibTeX V. Obsilova, K. Honzejkova and T. Obsil Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions International Journal of Molecular Sciences 22(24), 2021 DOI BibTeX S. Leysen, R. J. Burnley, E. Rodriguez, L.-G. Milroy, L. Soini, C. J. Adamski, L. Nitschke, R. Davis et al. A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1 Journal of Molecular Biology 433(19), 2021 DOI BibTeX D. L. Santo, O. Petrvalska, V. Obsilova, C. Ottmann and T. Obsil Stabilization of Protein\textendashProtein Interactions between CaMKK2 and 14\textendash3\textendash3 by Fusicoccins ACS Chemical Biology 15(11), 2020 DOI BibTeX V. Obsilova and T. Obsil The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases International Journal of Molecular Sciences 21(22), 2020 DOI BibTeX M. Wolter, D. L. Santo, P. Herman, A. Ballone, F. Centorrino, T. Obsil and C. Ottmann Interaction of an IpkappaBpalpha Peptide with 14-3-3 ACS Omega 5(10), 2020 DOI BibTeX D. Kalabova, F. Filandr, M. Alblova, O. Petrvalska, M. Horvath, P. Man, T. Obsil and V. Obsilova 14-3-3 protein binding blocks the dimerization interface of caspase-2 The FEBS Journal 287(16), 2020 DOI BibTeX A. Smidova, K. Stankova, O. Petrvalska, J. Lazar, H. Sychrova, T. Obsil, O. Zimmermannova and V. Obsilova The activity of Saccharomyces cerevisiae Na\mathplus, K\mathplus/H\mathplus antiporter Nha1 is negatively regulated by 14-3-3 protein binding at serine 481 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1866(12), 2019 DOI BibTeX K. Psenakova, R. Hexnerova, P. Srb, V. Obsilova, V. Veverka and T. Obsil The redox-active site of thioredoxin is directly involved in apoptosis signal-regulating kinase 1 binding that is modulated by oxidative stress The FEBS Journal 287(8), 2019 DOI BibTeX K. Psenakova, K. Kohoutova, V. Obsilova, M. J. Ausserlechner, V. Veverka and T. Obsil Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics Cells 8(8), 966, 2019 DOI BibTeX M. Alblova, A. Smidova, D. Kalabova, D. L. Santo, T. Obsil and V. Obsilova Allosteric activation of yeast enzyme neutral trehalase by calcium and 14-3-3 protein Physiol. Res. 68(2), 147-160, 2019 DOI BibTeX A. Smidova, M. Alblova, D. Kalabova, K. Psenakova, M. Rosulek, P. Herman, T. Obsil and V. Obsilova 14-3-3 protein masks the nuclear localization sequence of caspase-2 The FEBS Journal 285(22), 2018 DOI BibTeX S. Kylarova, K. Psenakova, P. Herman, V. Obsilova and T. Obsil CaMKK2 kinase domain interacts with the autoinhibitory region through the N-terminal lobe including the RP insert Biochimica et Biophysica Acta (BBA) - General Subjects 1862(10), 2018 DOI BibTeX K. Psenakova, O. Petrvalska, S. Kylarova, D. L. Santo, D. Kalabova, P. Herman, V. Obsilova and T. Obsil 14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2) Biochimica et Biophysica Acta (BBA) - General Subjects 1862(7), 2018 DOI BibTeX L. M. Stevers, E. Sijbesma, M. Botta, C. MacKintosh, T. Obsil, I. Landrieu, Y. Cau, A. J. Wilson et al. Modulators of 14-3-3 Protein-Protein Interactions Journal of Medicinal Chemistry 61(9), 3755-3778, 2018 DOI BibTeX M. Alblova, A. Smidova, V. Docekal, J. Vesely, P. Herman, V. Obsilova and T. Obsil Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1 Proceedings of the National Academy of Sciences 114(46), 2017 DOI BibTeX M. Kacirova, J. Novacek, P. Man, V. Obsilova and T. Obsil Structural Basis for the 14-3-3 Protein-Dependent Inhibition of Phosducin Function Biophysical Journal 112(7), 2017 DOI BibTeX S. Kylarova, D. Kosek, O. Petrvalska, K. Psenakova, P. Man, J. Vecer, P. Herman, V. Obsilova et al. Cysteine residues mediate high-affinity binding of thioredoxin to ASK1 The FEBS Journal 283(20), 2016 DOI BibTeX O. Petrvalska, D. Kosek, Z. Kukacka, Z. Tosner, P. Man, J. Vecer, P. Herman, V. Obsilova et al. Structural Insight into the 14-3-3 Protein-dependent Inhibition of Protein Kinase ASK1 (Apoptosis Signal-regulating kinase 1) Journal of Biological Chemistry 291(39), 2016 DOI BibTeX M. Kacirova, D. Kosek, A. Kadek, P. Man, J. Vecer, P. Herman, V. Obsilova and T. Obsil Structural Characterization of Phosducin and Its Complex with the 14-3-3 Protein Journal of Biological Chemistry 290(26), 2015 DOI BibTeX D. Kosek, S. Kylarova, K. Psenakova, L. Rezabkova, P. Herman, J. Vecer, V. Obsilova and T. Obsil Biophysical and Structural Characterization of the Thioredoxin-binding Domain of Protein Kinase ASK1 and Its Interaction with Reduced Thioredoxin Journal of Biological Chemistry 289(35), 2014 DOI BibTeX L. Rezabkova, M. Kacirova, M. Sulc, P. Herman, J. Vecer, M. Stepanek, V. Obsilova and T. Obsil Structural Modulation of Phosducin by Phosphorylation and 14-3-3 Protein Binding Biophysical Journal 103(9), 2012 DOI BibTeX
